解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::It is naive and incorrect to use the proportions of successful operations to compare the performance of surgeons because the patients' risk profiles are different. In this paper, we explore the use of risk-adjusted procedures to compare the performance of surgeons. One such risk-adjusted statistic is the standardized ...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7310
更新日期:2017-07-20 00:00:00
abstract::Combining multiple markers can improve classification accuracy compared with using a single marker. In practice, covariates associated with markers or disease outcome can affect the performance of a biomarker or biomarker combination in the population. The covariate-adjusted receiver operating characteristic (ROC) cur...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7274
更新日期:2017-07-10 00:00:00
abstract::Correct specification of the inverse probability weighting (IPW) model is necessary for consistent inference from a marginal structural Cox model (MSCM). In practical applications, researchers are typically unaware of the true specification of the weight model. Nonetheless, IPWs are commonly estimated using parametric...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7266
更新日期:2017-06-15 00:00:00
abstract::We studied the problem of testing a hypothesized distribution in survival regression models when the data is right censored and survival times are influenced by covariates. A modified chi-squared type test, known as Nikulin-Rao-Robson statistic, is applied for the comparison of accelerated failure time models. This st...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7244
更新日期:2017-05-30 00:00:00
abstract::Prevalent sampling is frequently a convenient and economical sampling technique for the collection of time-to-event data and thus is commonly used in studies of the natural history of a disease. However, it is biased by design because it tends to recruit individuals with longer survival times. This paper considers est...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7184
更新日期:2017-04-15 00:00:00
abstract::In studies with survival or time-to-event outcomes, a competing risk is an event whose occurrence precludes the occurrence of the primary event of interest. Specialized statistical methods must be used to analyze survival data in the presence of competing risks. We conducted a review of randomized controlled trials wi...
journal_title:Statistics in medicine
pub_type: 杂志文章,评审
doi:10.1002/sim.7215
更新日期:2017-04-15 00:00:00
abstract::Outcome-dependent sampling (ODS) scheme is a cost-effective sampling scheme where one observes the exposure with a probability that depends on the outcome. The well-known such design is the case-control design for binary response, the case-cohort design for the failure time data, and the general ODS design for a conti...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7195
更新日期:2017-03-15 00:00:00
abstract::We consider recurrent events of the same type that occur during alternating restraint and non-restraint time periods. This research is motivated by a study on juvenile recidivism, where the probationers were followed for re-offenses during alternating placement periods and free-time periods. During the placement perio...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7150
更新日期:2017-02-20 00:00:00
abstract::Arming the immune system against cancer has emerged as a powerful tool in oncology during recent years. Instead of poisoning a tumor or destroying it with radiation, therapeutic cancer vaccine, a type of cancer immunotherapy, unleashes the immune system to combat cancer. This indirect mechanism-of-action of vaccines p...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7157
更新日期:2017-02-20 00:00:00
abstract::Using both simulated and real datasets, we compared two approaches for estimating absolute risk from nested case-control (NCC) data and demonstrated the feasibility of using the NCC design for estimating absolute risk. In contrast to previously published results, we successfully demonstrated not only that data from a ...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7143
更新日期:2017-02-10 00:00:00
abstract::We propose a new design for dose finding for cytotoxic agents in two ordered groups of patients. By ordered groups, we mean that prior to the study there is clinical information that would indicate that for a given dose one group would be more susceptible to toxicities than patients in the other group. The designs are...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7133
更新日期:2017-01-30 00:00:00
abstract::Toxicity probability interval designs have received increasing attention as a dose-finding method in recent years. In this study, we compared the two-stage, likelihood-based continual reassessment method (CRM), modified toxicity probability interval (mTPI), and the Bayesian optimal interval design (BOIN) in order to e...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7043
更新日期:2017-01-30 00:00:00
abstract::The development of drugs and biologicals whose mechanisms of action may extend beyond their target indications has led to a need to identify unexpected potential toxicities promptly even while blinded clinical trials are under way. One component of recently issued FDA rules regarding safety reporting requirements rais...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7129
更新日期:2017-01-15 00:00:00
abstract::We propose a joint model to analyze the structure and intensity of the association between longitudinal measurements of an ordinal marker and time to a relevant event. The longitudinal process is defined in terms of a proportional-odds cumulative logit model. Time-to-event is modeled through a left-truncated proportio...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7065
更新日期:2016-12-10 00:00:00
abstract::Observational studies provide a rich source of information for assessing effectiveness of treatment interventions in many situations where it is not ethical or practical to perform randomized controlled trials. However, such studies are prone to bias from hidden (unmeasured) confounding. A promising approach to identi...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7051
更新日期:2016-12-10 00:00:00
abstract::Flexible survival models are in need when modelling data from long term follow-up studies. In many cases, the assumption of proportionality imposed by a Cox model will not be valid. Instead, a model that can identify time varying effects of fixed covariates can be used. Although there are several approaches that deal ...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7088
更新日期:2016-12-10 00:00:00
abstract::The sample size required for a cluster randomised trial is inflated compared with an individually randomised trial because outcomes of participants from the same cluster are correlated. Sample size calculations for longitudinal cluster randomised trials (including stepped wedge trials) need to take account of at least...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7028
更新日期:2016-11-20 00:00:00
abstract::Motivated by a study for soft tissue sarcoma, this article considers the analysis of diseases recurrence and survival. A multivariate frailty hazard model is established for joint modeling of three correlated time-to-event outcomes: local disease recurrence, distant disease recurrence (metastasis), and death. The goal...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7030
更新日期:2016-11-20 00:00:00
abstract::A new testing approach is described for improving statistical tests of independence in sets of tables stratified on one or more relevant factors in case of categorical (nominal or ordinal) variables. Common tests of independence that exploit the ordinality of one of the variables use a restricted-alternative approach....
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7006
更新日期:2016-11-10 00:00:00
abstract::The focus of this paper is dietary intervention trials. We explore the statistical issues involved when the response variable, intake of a food or nutrient, is based on self-report data that are subject to inherent measurement error. There has been little work on handling error in this context. A particular feature of...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7011
更新日期:2016-11-10 00:00:00
abstract::In this paper, an approach to estimating the cumulative mean function for history process with time dependent covariates and right censored time-to-event variable is developed using the combined technique of joint modeling and inverse probability weighting method. The consistency of proposed estimator is derived. Theo...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.6998
更新日期:2016-11-10 00:00:00
abstract::Epidermal nerve fibre (ENF) density and morphology are used to study small fibre involvement in diabetic, HIV, chemotherapy induced and other neuropathies. ENF density and summed length of ENFs per epidermal surface area are reduced, and ENFs may appear more clustered within the epidermis in subjects with small fibre ...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7009
更新日期:2016-10-30 00:00:00
abstract::We propose a two-step procedure to personalize drug dosage over time under the framework of a log-linear mixed-effect model. We model patients' heterogeneity using subject-specific random effects, which are treated as the realizations of an unspecified stochastic process. We extend the conditional quadratic inference ...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7016
更新日期:2016-10-30 00:00:00
abstract::When estimating causal effects, unmeasured confounding and model misspecification are both potential sources of bias. We propose a method to simultaneously address both issues in the form of a semi-parametric sensitivity analysis. In particular, our approach incorporates Bayesian Additive Regression Trees into a two-p...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.6973
更新日期:2016-09-10 00:00:00
abstract::The incremental life expectancy, defined as the difference in mean survival times between two treatment groups, is a crucial quantity of interest in cost-effectiveness analyses. Usually, this quantity is very difficult to estimate from censored survival data with a limited follow-up period. The paper develops estimati...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.6951
更新日期:2016-09-10 00:00:00
abstract::Most phase I dose-finding methods in oncology aim to find the maximum-tolerated dose from a set of prespecified doses. However, in practice, because of a lack of understanding of the true dose-toxicity relationship, it is likely that none of these prespecified doses are equal or reasonably close to the true maximum-to...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.6933
更新日期:2016-09-10 00:00:00
abstract::There has been substantial statistical literature in the last several decades on assessing agreement, and coverage probability approach was selected as a preferred index for assessing and improving measurement agreement in a core laboratory setting. With this approach, a satisfactory agreement is based on pre-specifie...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.6903
更新日期:2016-08-15 00:00:00
abstract::Multilevel and longitudinal studies are frequently subject to missing data. For example, biomarker studies for oral cancer may involve multiple assays for each participant. Assays may fail, resulting in missing data values that can be assumed to be missing completely at random. Catellier and Muller proposed a data ana...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.6811
更新日期:2016-07-30 00:00:00
abstract::We propose an innovative and practically relevant clustering method to find common task-related brain regions among different subjects who respond to the same set of stimuli. Using functional magnetic resonance imaging (fMRI) time series data, we first cluster the voxels within each subject on a voxel by voxel basis. ...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.6906
更新日期:2016-07-10 00:00:00
abstract::The receiver operating characteristic (ROC) curve is a popular technique with applications, for example, investigating an accuracy of a biomarker to delineate between disease and non-disease groups. A common measure of accuracy of a given diagnostic marker is the area under the ROC curve (AUC). In contrast with the AU...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.6863
更新日期:2016-06-15 00:00:00
abstract::Observational cohort studies often feature longitudinal data subject to irregular observation. Moreover, the timings of observations may be associated with the underlying disease process and must thus be accounted for when analysing the data. This paper suggests that multiple outputation, which consists of repeatedly ...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.6829
更新日期:2016-05-20 00:00:00
abstract::Group sequential hypothesis testing is now widely used to analyze prospective data. If Monte Carlo simulation is used to construct the signaling threshold, the challenge is how to manage the type I error probability for each one of the multiple tests without losing control on the overall significance level. This paper...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.6805
更新日期:2016-04-30 00:00:00
abstract::Lower urinary tract symptoms can indicate the presence of urinary tract infection (UTI), a condition that if it becomes chronic requires expensive and time consuming care as well as leading to reduced quality of life. Detecting the presence and gravity of an infection from the earliest symptoms is then highly valuable...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.6786
更新日期:2016-04-15 00:00:00
abstract::Group sequential testing procedures have been proposed as an approach to conserving resources in biomarker validation studies. Previously, we derived the asymptotic properties of the sequential empirical positive predictive value (PPV) and negative predictive value (NPV) curves, which summarize the predictive accuracy...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.6790
更新日期:2016-04-15 00:00:00
abstract::In many medical applications, combining information from multiple biomarkers could yield a better diagnosis than any single one on its own. When there is a lack of a gold standard, an algorithm of classifying subjects into the case and non-case status is necessary for combining multiple markers. The aim of this paper ...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.6780
更新日期:2016-04-15 00:00:00
abstract::A personalized treatment strategy formalizes evidence-based treatment selection by mapping patient information to a recommended treatment. Personalized treatment strategies can produce better patient outcomes while reducing cost and treatment burden. Thus, among clinical and intervention scientists, there is a growing...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.6783
更新日期:2016-04-15 00:00:00
abstract::Surrogate endpoint validation has been well established by the meta-analytical correlation-based approach as outlined in the seminal work of Buyse et al. (Biostatistics, 2000). Surrogacy can be assumed if strong associations on individual and study levels can be demonstrated. Alternatively, if an effect on a true endp...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.6778
更新日期:2016-03-30 00:00:00
abstract::The 'landmark' and 'Simon and Makuch' non-parametric estimators of the survival function are commonly used to contrast the survival experience of time-dependent treatment groups in applications such as stem cell transplant versus chemotherapy in leukemia. However, the theoretical survival functions corresponding to th...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.6765
更新日期:2016-03-30 00:00:00
abstract::Confounding factors are commonly encountered in observational studies. Several confounder-adjusted tests to compare survival between differently exposed subjects were proposed. However, only few studies have compared their performances regarding type I error rates, and no study exists evaluating their type II error ra...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.6777
更新日期:2016-03-30 00:00:00
abstract::When analyzing time to disease recurrence, we sometimes need to work with data where all the recurrences are recorded, but no information is available on the possible deaths. This may occur when studying diseases of benign nature where patients are only seen at disease recurrences or in poorly-designed registries of b...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.6766
更新日期:2016-03-30 00:00:00